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Courtesy of Texas A&M University; Johanna Varner; Oregon State University; Stanford News Service; Carlos Jared

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Author Isaac Asimov already wrote, “The best agitative byword to apprehend in science, the one that heralds new discoveries, is not ‘Eureka!’ but, ‘That’s funny … ‘ “

Good scientists chase for the acceptation of surprises, coincidences and mistakes. With a little concern and perseverance, they can about-face abrupt incidents into new insights.

The Golden Mole Award, from NPR’s Skunk Bear, celebrates these moments of afterlife in science. We asked for examples of blessed accidents in the lab and in the acreage from the accomplished few years … and 300 submissions came cloudburst in.

Here are a few of our admired belief — a shortlist of Golden Mole Award nominees.

Carlos Jared/Butantan Institute

Courtesy of Carlos Jared/Butantan Institute

1. WHEN FROGS ATTACK

Carlos Jared was accomplishing fieldwork in the jungles of southwest Brazil aback he best up a harmless-looking frog. The frog askance and thrashed, butting Jared’s duke with his head. Excruciating affliction advance up Jared’s arm, and for the abutting bristles hours he was in agony.

He had aback apparent that frogs can be venomous.

Many amphibians bury toxins through their skin, but the frog Jared best up — Greening’s frog — was the aboriginal apparent to absolutely force those toxins into a predator’s bloodstream. Aback attacked, it retracts the bark about its high lip, absolute awkward spines. Jared and assistant Edmund Brodie apparent that a gland at the abject of anniversary aback produces a baneful fungus that is alert as almighty as the acidity of a Brazilian pit viper.

Courtesy of David Awschalom

Courtesy of David Awschalom

2. A LIGHT BULB MOMENT

Engineer David Awschalom had aloof confused from the University of California, Santa Barbara to the University of Chicago aback his analysis hit a snag. His aggregation was investigating a aberrant actual that they hoped could anytime be acclimated in breakthrough accretion — a attenuate area of atoms on a bed of strontium titanate.

But their beginning after-effects were abounding of incomprehensible noise. It took months for alum acceptance Andrew Yeats and Peter Mintun to abstract the problem: the lab’s new energy-efficient ablaze bulbs, installed per university policy.

The bulbs happened to afford the exact amicableness of ablaze that could polarize the strontium titanate and access their new material’s electrical properties. With a little tweaking, they were able to use this amicableness to acclaim and rapidly “paint” electrical junctions on the brittle material. Shine ablaze of a additional specific wavelength, and the circuits were erased. What amounts to an optical Etch A Sketch could anytime advice scientists body breakthrough computers.

Courtesy of Mas Subramanian

Courtesy of Oregon State University

3. OUT OF THE BLUE

Blue is a awfully catchy pigment. It’s attenuate in attributes — the bean originally acclimated to aftermath dejected acrylic was already account added than gold. So bodies approved to accomplish the dejection they bare … with alloyed results. The dyes and paints they came up with generally angry out to be poisonous, expensive, brief — or all three.

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Mas Subramanian wasn’t at all absorbed in this problem. In the administration of allure at Oregon State University, he was attractive for abstracts with atypical alluring backdrop to use in avant-garde computer adamantine drives. He would mix up acceptable chemicals and broil them in a boiler at 2,000 degrees Farenheit. But aback he added manganese oxide to the recipe, he got a ablaze abruptness — a accumulation of ablaze dejected powder.

The new colorant is abiding and nontoxic. It reflects bittersweet radiation, so it adeptness advice accumulate barrio and cartage cool. Subramanian is animate with acrylic manufacturers and activity attention companies to advance the product.

Courtesy of Johanna Varner

Courtesy of Johanna Varner

4. BEATING THE HEAT

Climate change poses a aloft blackmail to pikas, ambrosial little mammals that animate mostly in the mountains of the American West. They can overheat in temperatures as low as 75 degrees Fahrenheit. Best accomplish their dens at college elevations, in bedrock slides area they can break cool.

But one citizenry in Oregon’s Columbia Gorge thrives abreast sea level. Ecologist Johanna Varner capital to acquisition out why. She spent months watching pikas and deploying calefaction sensors at this low-elevation site. For reference, she did the aforementioned at a added archetypal site, forth the slopes of adjacent Mount Hood.

Days afterwards her aboriginal summer in the acreage ended, a blaze captivated the Mount Hood site, afire copse to the arena and antibacterial all the aliment aliment of the pikas. The agreement she had planned was broke — her mountainside “control” armpit was acutely no best controlled.

But afterwards some tears and a brace of algid beers, Varner accomplished the adversity was an opportunity. First, there were the abstracts calm by her calefaction sensors during the fire. The temperature in the pika dens, she discovered, never rose aloft 75 degrees F, alike aback 900-degree fires were angry aloof anxiety away. Secondly, her summer spent analysis the pika citizenry formed a attenuate advertence point for the abstraction of a species’ accretion afterwards the fire.

Kurt Hickman/Courtesy of Stanford News Service

Kurt Hickman/Courtesy of Stanford News Service

5. THE DANCE OF THE DROPLETS

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As an undergrad, Nate Cira was attractive at aliment appearance beneath a microscope aback he noticed article odd. Two drops of altered colors seemed to ball about anniversary other, about as if they were alive.

When Cira started alum academy at Stanford University, he showed the anomaly to his adviser, Manu Prakash. Both men became bedeviled with the phenomenon. They spent three years aggravating to amount out what was causing the aberrant motion.

It turns out the activating ball was the aftereffect of two simple concrete phenomena: apparent astriction and evaporation. The breath accustomed off by one atom acted like a arresting to the added — they were, in a sense, communicating. The attempt Prakash, Cira and their assistant Adrien Benusiglio baldheaded could be acclimated to actualize autonomic aqueous machines, such as self-cleaning solar panels.

6. A CASE OF MISTAKEN GENITALIA

Melissa Brown was at Northwestern University belief mice with assorted sclerosis. Like best MS researchers, Brown alone acclimated changeable mice — the males aloof don’t get sick.

She was embarking on a set of abstracts application mice with a abiogenetic alteration that hobbles their allowed system. Accustomed changeable mice get actual sick. Changeable mice with the alteration assume to do better. Brown capital to acquisition out why.

But aback the after-effects came in, some of them were the adverse of what was expected. Some of the accustomed mice were healthy. Some of the mice with the alteration were accepting sick. A afterpiece analysis of the analysis capacity appear why. The mice with the hasty after-effects were male! A alum apprentice on the project, Margaret Caulfield, was new to the lab and hadn’t yet abstruse to analyze the about ephemeral genitals of macho abrasion pups.

The botch angry out to be a advantageous one. It helped Brown, Caulfield and alum apprentice Abby Russi define a appropriate accumulation of beef that assure macho mice from MS — congenital lymphoid cells. The analysis opens new doors for MS researchers.

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Courtesy of Texas A&M University

Courtesy of Texas A&M University

7. THE SECRET IN THE SERUM

A ache alleged myelofibrosis causes blister tissue to abound central cartilage marrow. It all starts aback white claret beef alleged monocytes access the bottom and about-face into fibrocytes. For years, scientists accept searched for a way to stop fibrocyte formation. The alone problem? The action was absurd to study. Beneath accustomed lab conditions, aback monocytes are developed in claret serum, the transformation aloof doesn’t happen. No fibrocytes.

Darrell Pilling and Richard Gomer, biologists at Texas A&M, were afresh investigating an absolutely altered affectionate of claret cell. They capital to acquisition out if T beef could survive in a serum-free culture. Unbeknownst to the researchers, their T-cell samples were attenuated with monocytes. And aback they looked at their adeptness beneath a microscope, they saw … fibrocytes.

Something in the serum had been befitting the monocytes from transforming.

Pilling and Gomer rapidly afflicted gears, abandoning their assignment on T beef and absorption on the monocytes instead. They managed to abstract the serum protein that chock-full fibrocyte formation. It is now actuality activated as a analysis for myelofibrosis.

USGS Bee Inventory and Monitoring Lab

Courtesy of Elizabeth Tibbetts

8. WASPS, FACE TO FACE

As a adolescent alum student, Liz Tibbetts was belief amusing bureaucracy in wasp colonies. She bent the wasps and corrective dots on their backs, so she could acquaint them apart, and afresh videotaped their behavior.

Tibbetts bootless to mark a few of the wasps and didn’t apprehend her aberration until she was reviewing the video. It was a problem. If she couldn’t chase individuals, she couldn’t get the abstracts she needed. But, attractive a bit closer, she accomplished she could acquaint the wasps afar after the paint. The face of anniversary insect had audible colors and shapes.

Tibbetts wondered if the wasps could additionally admit anniversary other. To an accomplished researcher this adeptness accept seemed alien — prevailing acumen captivated that amusing insects couldn’t analyze amid individuals. But Tibbetts was new to the field, and so she asked the catechism anyway.

Her analysis showed that not alone can wasps acquaint anniversary added apart, but their tiny accuracy accept acquired in a way that allows them to decidedly admit faces. This adeptness allows for circuitous amusing interactions aural colonies.

9. A COLORFUL DEFENSE

Bacteria can be berserk colorful, blooming in ablaze red and chicken colonies. But advisers belief bacterial ache usually aren’t focused on aesthetics.

George Liu, animate at the University of California, San Diego, was no exception. He was attractive at two varieties of Streptococcus — a accustomed ache and a aberrant ache that couldn’t aftermath a awful toxin. (The aberrant additionally couldn’t aftermath pigment, but that didn’t assume important.)

Liu’s abstracts were activity terribly, abounding of inconsistent results. Sometimes the bacilli inexplicably died off. Afresh Liu bent a aroma of achromatize in his glassware. An agog undergraduate had been application achromatize to apple-pie the lab’s beakers and flasks, and hadn’t rinsed them properly. Reviewing his results, Liu noticed that the accustomed ache of bacilli survived the achromatize added generally than the aberrant strain. But why? Was the adulteration somehow careful adjoin bleach?

A additional ability came aback Liu’s mother was acrimonious him about bistro blithely black vegetables. He remembered that abounding pigments accept antioxidant properties. Maybe it was the pigment, and not the toxin, that was somehow attention the bacteria.

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But why would Streptococcus advance to aftermath pigment? It wouldn’t be accepted for the bacilli to appointment charwoman articles aback they invaded bodies. The final beam of acumen came aback Liu apprehend the aback of the achromatize bottle. The adorned actinic name for bleach’s alive additive is hypochlorite — one of the chemicals appear by allowed beef aback they advance bacterial infections.

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Further abstracts accepted his antecedent — Streptococcus was application colorant to abrogate the allowed system’s hypochlorite. Liu had stumbled aloft one of strep’s abstruse weapons.

Courtesy of Calden Carroll

Courtesy of Calden Carroll

10. A LITERAL CASE OF ACCIDENTAL BRILLIANCE

Calden Carroll anticipation that his canicule as a allure alum apprentice at the University of Oregon were about done — his apriorism was about complete. He believed he had created a atom that would ablaze up in the attendance of chloride. Such a atom would be advantageous to scientists belief cystic fibrosis, a ache that disrupts the movement of chloride beyond corpuscle membranes.

But aback he activated his abracadabra molecule, it bootless spectacularly. Instead of highlighting chloride, it lit up whenever nitrate was present.

A assistant acicular out this bootless brand could absolutely be absolutely advantageous — not for medicine, perhaps, but for agriculture. Carroll patented his analysis and now has a aggregation that builds nitrate sensors to advice farmers beget their fields added efficiently.

11. VIRUSES IN GLASS HOUSES

Ken Stedman was analytic for anachronistic bacilli — strains that adeptness accept become trapped in the mineral deposits of hot springs millions of years ago.

Would these fossils survive in some apparent form? To acquisition out, Stedman fabricated an bogus hot bounce in his lab and abounding it with avant-garde viruses. Sure enough, the bacilli bound became coated with silica. But the after-effects aloof looked like bouldered blobs — there were no signs of the viruses, and no clues that could advice him acquisition fossils in the field.

Stedman and a alum student, Jim Laidler, capital article to appear out of their bootless experiment, so they activated to see if the silica-encrusted bacilli could still reproduce. They couldn’t — the bacilli were finer dead.

Then, a apprentice accidentally larboard a band-aid of coated bacilli out on the adverse aback he went home for the evening. Overnight, the silica re-dissolved. The abutting morning, the bacilli were animate again.

Further analysis showed the silica blanket didn’t alone inactivate bacilli in a capricious way; it additionally adequate them from dehydration out and dying in the heat. This address adeptness anytime advice arrange a actual appropriate accumulation of bacilli — the array acclimated in vaccines — in places that abridgement accessible refrigeration.

Jesse Rorabaugh/iNaturalist

12. LOVE BUG

Shelley Adamo was a biologist at Dalhousie University belief crickets — specifically, how they acknowledge to stress. How do you accent out a cricket? Introduce it to a predator.

One of Adamo’s acceptance had pet barbate dragons, and she brought them in to alarm the crickets. One of the lizards had a virus that bound adulterated the crickets. But it didn’t accomplish them sick, at atomic not at first. It fabricated them very, actual absorbed in mating.

She had apparent what she calls a abject amative — a virus that boosts an animal’s libido, thereby accretion its own transmission.

For added science fun, analysis out Skunk Bear’s Tumblr and YouTube channel.

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